SEARCH OF REGULATORS AMONG (7-CHLOROQUINOLINE-4-YLTHIO)CARBONIC ACIDS AND TRIAZOLES OF ANTHRACENDIONE FOR MICROCLONAL PROPAGATION OF PLANTS

Description

The use of rhizogenesis stimulators during microclonal propagation of plants significantly increases efficiency and
reduces costs. The modern direction in the design of effective non-toxic substances is molecular modeling based on
known natural and synthetic compounds. An important place as synthons for development is occupied by nitrogencontaining heterocycles, in particular, pyridine, quinoline, anthracenedione. The growth-stimulating properties of
(7-chloroquinoline-4-ylthio)carboxylic acids and new triazole derivatives based on anthracenedione were
investigated. Lipophilicity was analyzed using the ACD-I-Labs computer program. The log P for neutral forms and the
value of the distribution coefficient log D at pH = 7 for the investigated compounds were determined. Determination
of the precise action of compounds in silico was carried out with the help of computer programs GUSAR (Germany),
TEST (USA) and on the in vitro model of the study of progressive sperm motility. The effect on rhizogenesis was
evaluated by the method of microclonal propagation of plants in the conditions of an in vitro microclonal laboratory
of pink rose (Rosa damascena Mill.) explants of the Lada variety.