The escalating threat of nuclear accidents, particularly stemming from terrorist activities and the potential deployment of nuclear weapons by rogue nations, is a pressing concern in contemporary times. Historic catastrophes such as those witnessed in Chornobyl (1986) and Fukushima (2011) underscore the profound risks associated with nuclear mishaps. Both in terms of the initial event and the subsequent management of its aftermath, which often entails significant dangers of acute radiation exposure. Compounding these concerns is the ongoing conflict in Ukraine, a nation housing numerous nuclear facilities, including the largest nuclear power plant in Europe located in Energodar, proximal to active conflict zones, thus emphasizing the immediacy of these issues.
Despite decades of research into radiation countermeasures for mitigating injuries resulting from radiation exposure. Particularly acute radiation syndrome, the absence of safe and efficacious anti- radiation approved by regulatory bodies like the United States Food and Drug Administration (FDA) remains a stark reality. The quest for effective radioprotective agents is imperative yet remains largely unmet.
Efforts to identify novel compounds with high potency and low toxicity, drawing from both natural and synthetic sources, have focused extensively on nitrogen-containing heterocycles, notably quinolines, and their derivatives, which exhibit significant biological activity. The structural versatility of quinolines presents opportunities for the conjugation of additional pharmacophores, thereby expanding their therapeutic potential. In recent years, a burgeoning body of literature has elucidated the antioxidant properties inherent in various quinoline derivatives, suggesting their promise as foundational elements in developing radioprotective medications with antioxidative mechanisms of action.
Title
Potential aminothiol-based radioprotective agents derivatized by quinolines
Potential aminothiol-based radioprotective agents derivatized by quinolines / Maryna Kornet, Olexandr Brazhko, Mykhailo Zavhorodnii, Nataliya Uzlenkova // The Twelfth International Conference on Radiation, Natural Sciences, Medicine, Engineering, Technology and Ecology (RAD 2024 Conference) : Book of Abstracts of RAD Conference, Montenegro, 17–21 June 2024. – 2024. – Р. 212.
Ключові слова:
Significantly, investigations into S-quinoline modified cysteamine