Investigation of aspects of the interaction of the indicators of lipid exchange, trombocitarian block of hemostasis, total body reactivity and their influence on the psychosomatic harmonization of the man in chronic inflammatory processes

Investigation of aspects of the interaction of the indicators of lipid exchange, trombocitarian block of hemostasis, total body reactivity and their influence on the psychosomatic harmonization of the man in chronic inflammatory processes
Back

Метадані

Опис

For the first time on the basis of clinical and laboratory researches were revealed the correlation of
indicators of lipid metabolism, platelet level of hemostasis and general reactivity in patients with
chronic inflammatory processes of the genital system. The new pathogenetic aspects of the course of
inflammatory diseases have been established. It has been shown that chronic inflammatory process
is accompanied by disorders of lipid metabolism. The degree of severity of these changes depends on
the severity of the inflammatory process, the reduction of phagocytic activity of polymorphonuclear
leukocytes and the activation of macrophage and specific cellular mechanisms, accompanied by auto-
intoxication. It is established that the frequency of atherogenic dyslipoproteinemias, as well as the
intensity of lipid peroxidation increases in accordance with the increase age of the examined patients.
Most atherogenic dyslipoproteinemias are found in patients with viral and chlamydial infections. The
summarized data of the correlation analysis allow us to establish that the growth of atherogenic
properties of blood plasma of patients with chronic inflammatory processes of the reproductive
system occurs in accordance with the increase of adhesive-aggregation properties of platelets and
damage of the vascular endothelium. These shifts occur in parallel with the predominance of the
monocyte-macrophage linkage of phagocytosis against the background of reduced activity of
neutrophils and cellular mechanisms of development of immunopathological reactions.

Назва

Investigation of aspects of the interaction of the indicators of lipid exchange, trombocitarian block of hemostasis, total body reactivity and their influence on the psychosomatic harmonization of the man in chronic inflammatory processes

Бібліографічний опис:

[1] Feingold KR, Grunfeld C. Lipids: a key player
in the battle between the host and microorganisms. Journal
of lipid research. 2012 Dec;53(12):2487-9. PubMed
PMID: 23075464. Pubmed Central PMCID: 3494250.
[2] Neubauer R.A. Free radicals and
antioxidants//Lancet. – 1994. – Vol.19, No344 – Р.1440-
1441.
[3] Pendergraft W, Rudolph E, Falk R, Jahn J,
Grimmler M, Hengst L, Jennette J, Preston G, . Proteinase
3 sidesteps caspases and cleaves p21Waf1/Cip1/Sdi1 to
induce endothelial cell apoptosis. Kidney International
2004;65(1):75-84.
[4] Introduction to Lipids and Lipoproteins.
Kenneth R Feingold, MD and Carl Grunfeld,
MD,PhD:https://www.ncbi.nlm.nih.gov/books/NBK3058
96/#top)
[5] T. Shibata, Y. Shimozu, C. Wakita, N. Shibata,
M. Kobayashi, S. Machida, R. Kato, H. Itabe, X. Zhu, L.M.
Sayre, K. Uchida,Lipid peroxidation modification of
protein generates Nε-(4-oxononanoyl)lysine as a pro-
inflammatory ligand Journal of Biological Chemistry, 286
(2011), pp. 19943-19957
[6] K. Ishino, C. Wakita, T. Shibata, S. Toyokuni,
S. Machida, S. Matsuda, T. Matsuda, K. Uchida Lipid
peroxidation generates a body odor component trans-2-
nonenal covalently bound to protein in vivo Journal of
Biological Chemistry, 285 (2010), pp. 15302-15313
[7] D. Weismann, C.J. Binder The innate immune
response to products of phospholipid peroxidation
Biochimica et Biophysica Acta, 1818 (2012), pp. 2465-
2475
[8] Lenting P. J., Casari C., Christophe O. D.,
Denis C. V. von Willebrand factor: the old, the new and the
unknown. Journal of Thrombosis and Haemostasis.
2012;10(12):2428–2437. doi: 10.1111/jth.12008

Видавець:

FRENCH-UKRAINIAN JOURNAL OF CHEMISTRY (2019, VOLUME 07, ISSUE 02)

Ключові слова:

reproductive health, chronic inflammatory processes, lipid metabolism, platelet level of hemostasis, reactivity, resistance, psychosomatic harmonization